Pair Name	Pterostilbene, Sunitinib
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Biological Phenomena	Induction-->Oxidative Stress
Gene Regulation	Down-regulation	Expression	PDZD8	hsa118987
In Vitro Model	TMK-1	Gastric adenocarcinoma	Homo sapiens (Human)	CVCL_4384
	MKN74	Gastric tubular adenocarcinoma	Homo sapiens (Human)	CVCL_2791
In Vivo Model	Subcutaneous tumor models were established by inoculating cancer cells (MKN74: 5×10⁶ per mouse, TMK-1: 1×107 per mouse) into the scapular subcutaneous tissues of nude mice on Day 0.
Result	PDZD8 may be a newly discovered off-target for SUN, and that the combined use of PTE with SUN significantly promotes antitumor activity in gastric cancer cell lines. The combined use of SUN and PTE might be a new molecular-targeted therapy for gastric cancer.